Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin

The cytotoxic effect of lipopolysaccharide (LPS) on cultivated bovine aortic endothelial cells was determined. This LPS-induced cytotoxicity was attenuated by diosmin. That means, the IC50 value of LPS in the combination with 8 mumol/l diosmin was shifted from 31 to 70 ng/ml in a concentration dependent manner. As a hypothesis it was suggested, that the inhibition of LPS-induced cytotoxicity in bovine aortic endothelial cell cultures by diosmin could be probably mediated via inhibition of tyrosine kinases.