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Related Experiment Videos

[Membrane receptor disorders in bronchial asthma].

V N Mineev, E A Shpetnaia, E B Shadrin

    Terapevticheskii Arkhiv
    |May 11, 1999
    PubMed
    Summary

    Erythrocyte impedance characteristics differ in atopic and bacterial asthma, indicating distinct membrane lipid matrix conditions. This research suggests potential new treatments for bacterial asthma using phospholipids.

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    [Evaluating the activity of the apoptosis-regulating genes from Bcl-2, Bax expression, and caspase-3 activity in bronchial epithelial cells in patients with asthma].

    Arkhiv patologii·2011

    Area of Science:

    • Biophysics
    • Cell Biology
    • Respiratory Medicine

    Background:

    • Bronchial asthma (BA) involves complex cellular changes.
    • Erythrocyte membrane properties may reflect systemic conditions like BA.
    • Understanding these properties can aid in diagnosing and treating asthma subtypes.

    Purpose of the Study:

    • To characterize erythrocyte electrical impedance in bronchial asthma (BA).
    • To correlate impedance parameters with the cell membrane lipid matrix.
    • To differentiate between atopic and bacterial BA based on erythrocyte properties.

    Main Methods:

    • Electrical impedance parameters (capacity, temperature-dependent) were measured in 164 BA patients, 19 pre-asthma patients, 21 relatives, and 36 controls.
    • Low-temperature hyperosmolarity hemolysis was assessed before and after modulation with adrenergic and lipotropic agents.
    • Modified S. Takashima et al. (1988) method was employed for impedance measurements.

    Main Results:

    • Atopic BA showed increased erythrocyte electrical capacity and altered responses to adrenaline/obzidan.
    • Atopic BA exhibited high initial erythrocyte resistance to low-temperature hyperosmolarity.
    • Bacterial asthma presented opposite trends in impedance and hemolysis parameters compared to atopic BA.

    Conclusions:

    • Atopic BA is associated with low erythrocyte membrane microviscosity.
    • Bacterial asthma is linked to high erythrocyte membrane microviscosity.
    • Essential phospholipids are proposed for treating bacterial BA based on these findings.

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