[Preventive chronotherapy with capoten in hypertensive outpatients]

The study was made of effectiveness of preventive chronotherapy (PC) and comparative benefit of preventive CT vs conventional therapy (CT) in 47 patients with essential hypertension (EH) stage I, II and III. The group on PC consisted of 25 patients. Capoten was given in a single dose from 12.5 to 50 mg 24 hours before the acrophase of blood pressure (BP). BP was measured 4-5 times a day for 4 days according to N. S. Korotkov's technique before the treatment and for the first 4 days of capoten treatment. A course of preventive CT was to continue for 30 days.