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Dorzolamide effect on ocular blood flow.

A Martinez1, F Gonzalez, C Capeans

  • 1Instituto Galego de Oftalmoloxia, Facultad de Medicina, Complejo Hospitalario Universitario de Santiago, Universidad de Santiago, Spain.

Investigative Ophthalmology & Visual Science
|May 11, 1999
PubMed
Summary

Topical dorzolamide improved ocular blood flow and reduced intraocular pressure in normal and glaucomatous eyes. This glaucoma medication enhances hemodynamic parameters, benefiting ocular circulation.

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Area of Science:

  • Ophthalmology
  • Ocular Hemodynamics
  • Glaucoma Research

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Ocular blood flow is a critical factor in glaucoma pathogenesis.
  • Understanding the hemodynamic effects of glaucoma medications is essential.

Purpose of the Study:

  • To investigate the impact of topical dorzolamide on ocular blood flow.
  • To compare these effects in normal and glaucomatous eyes.
  • To assess changes in ophthalmic and central retinal artery velocities and resistance.

Main Methods:

  • Color Doppler imaging was used to measure hemodynamic parameters.
  • Participants included patients with open-angle glaucoma and normal controls.
  • Measurements were taken before and after topical dorzolamide application.

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Main Results:

  • Dorzolamide increased peak-systolic velocity in the central retinal artery and end-diastolic velocity in both ophthalmic and central retinal arteries.
  • Resistance index decreased significantly in both arteries after dorzolamide use.
  • Intraocular pressure was significantly reduced in all groups.

Conclusions:

  • Topical dorzolamide positively influences hemodynamic parameters in ocular and periocular vessels.
  • Dorzolamide is beneficial for glaucoma treatment due to its IOP-lowering and ocular blood supply-improving effects.