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Related Experiment Videos

Hyperplastic-adenomatous polyposis syndrome.

R J Place1, C L Simmang

  • 1Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9156, USA.

Journal of the American College of Surgeons
|May 11, 1999
PubMed
Summary
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A new syndrome, hyperplastic-adenomatous polyposis syndrome (HAPS), is described in older adults with no family history of polyposis. This condition involves numerous polyps, primarily hyperplastic, and is linked to colon cancer.

Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Oncology

Background:

  • Familial adenomatous polyposis is a known inherited condition.
  • Sporadic cases of multiple polyps are rare.
  • No syndromes linking hyperplastic and adenomatous polyps were previously identified.

Purpose of the Study:

  • To describe a previously unreported syndrome of hyperplastic-adenomatous polyposis.
  • To characterize the clinical presentation and associations of this new syndrome.

Main Methods:

  • A 3-year retrospective review of six patients (ages 41-75) with 50-100 hyperplastic polyps and adenomas.
  • Clinical and pathological data were analyzed.

Main Results:

  • Patients presented with a mean age of 61.

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  • Most hyperplastic polyps were in the left colon, with larger ones resembling adenomas.
  • Three patients had invasive proximal colon cancer, confined to the bowel wall.

    • Conclusions:

    • Hyperplastic-adenomatous polyposis syndrome (HAPS) affects an older demographic with no family history of polyposis.
    • HAPS is characterized by fewer polyps, predominantly hyperplastic, and a strong association with colon adenocarcinoma.
    • This study reports a novel syndrome with significant implications for colorectal cancer risk stratification.