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Endocrine and behavioral traits in low-avoidance Sprague-Dawley rats.

K Uvnäs-Moberg1, E Björkstrand, P Salmi

  • 1Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

Regulatory Peptides
|May 11, 1999
PubMed
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Low-performing rats showed higher stress hormones and lower social hormones, indicating a submissive-defensive pattern. This hormonal profile likely explains their difficulty in learning avoidance responses.

Area of Science:

  • Neuroendocrinology
  • Behavioral Endocrinology
  • Animal Behavior

Background:

  • Two Sprague-Dawley rat stocks (A and B) exhibit distinct differences in conditioned avoidance response acquisition.
  • Understanding the neuroendocrine underpinnings of these behavioral differences is crucial.

Purpose of the Study:

  • To investigate the endocrine profiles of Sprague-Dawley rat stocks A and B.
  • To correlate hormonal levels with conditioned avoidance response performance and reactivity.

Main Methods:

  • Rats underwent conditioned avoidance training, startle reactivity tests, and open-field activity observations.
  • Plasma levels of insulin, gastrin, cholecystokinin (CCK), glucagon, somatostatin, oxytocin, and corticosterone were measured.

Main Results:

Related Experiment Videos

  • Stock B rats, with lower avoidance performance, exhibited higher startle reactivity, elevated plasma insulin and corticosterone, and reduced plasma gastrin and oxytocin.
  • A positive correlation was found between plasma oxytocin and gastrin levels and avoidance performance.
  • No significant differences in spontaneous locomotor activity were observed between the stocks.

Conclusions:

  • Stock B rats display hormonal profiles consistent with a submissive-defensive reaction pattern.
  • Emotional reactivity, influenced by endocrine factors, likely underlies the avoidance acquisition deficits in these rat stocks.