Chronic endometritis. A clinical and histopathological study

Area of Science:

• Gynecologic Pathology
• Reproductive Medicine
• Infectious Disease

Background:

• Chronic endometritis is a common finding in endometrial biopsies.
• Pelvic inflammatory disease (PID) is frequently associated with chronic endometritis.
• The etiology of PID and its link to chronic endometritis remains unclear in many cases.

Purpose of the Study:

• To highlight the frequency of chronic endometritis in biopsy material.
• To investigate the correlation between clinical symptoms and histological findings of chronic endometritis.
• To explore the association between chronic endometritis and pelvic inflammatory disease.

Main Methods:

• Histopathological examination of endometrial biopsy samples.
• Assessment of plasma cell infiltration in the endometrial stroma.
• Correlation analysis between clinical symptomatology and histological severity.
• Evaluation of associated conditions, particularly pelvic inflammatory disease.

Main Results:

• Chronic endometritis is a frequent diagnosis in endometrial biopsies.
• No significant correlation was observed between clinical symptoms and the severity of plasma cell infiltration.
• Pelvic inflammatory disease is the most commonly associated condition.
• A clinical cause could not be identified in 37.5% of cases with histologically confirmed chronic endometritis.

Conclusions:

• Chronic endometritis should be diagnosed more frequently.
• Histological assessment is crucial as clinical symptoms do not reliably indicate disease severity.
• Further research is needed to elucidate the etiology of pelvic inflammatory disease and its relationship with chronic endometritis.