[Use of cyclophosphamide in membranoproliferative glomerulonephritis]

A study was made of the effect of ciclofosfamide on the nephrotic syndrome, glomecular filtration rate, immuproteins clearance complement, and urinary sediment in 14 patients with membranoproliferative glomerulonephritis. It was found that the nephrotic syndrome disappeared in 7 out of 8 cases, the glomerular filtration rate increased significantly in 13 out of 14 patients, and there was no correlation between the action of the drug and the behavior of the immunoglobulins clearances, complement, and the urinary sediment. Neither was there found a correlation between the increased renal function and the histological spectrum.