[Dissemination of carcinogenic H3-dialkylhydrazines in the neuro-endocrine system and their antigonadotropic effect in rats]

Three hours after the dimethylhydrazine-3H (DMH) treatment specific radioactivity in the male rat pituitary, adrenal cortex, and the testes was higher than in the liver by 53, 85, and 108%, respectively. Tritium incorporation into the hypothalamus was higher than that by the liver, cerebral cortex, and the brain stem by 33, 69, and 44%, respectively. Three hours after the diethyl-hydrazine-3H (DEH) treatment the specific activities of the pituitary and the testes in male rats were higher than that of the liver by 57 and 108%, respectively. A single DMH and DEH administration to male rats in a dose of 21 mg per kg body weight resulted in a significant decrease of the pituitary FSH level (by 63 and 53%, respectively). The data obtained were indicative of a marked influence of the carcinogenic dialkylhydrazines on the rat neuroendocrin system.