Aseptic technique as a safety precaution in the preparation of antineoplastic agents

A subject of concern among personnel working in cancer chemotherapy treatment areas is the occupational hazard posed by the antineoplastic drugs. A review of the literature reveals a number of proposed safety precautions, including glove boxes, vertical air-flow hoods, masks, gloves, gowns, and routine medical examinations. The concept of using aseptic technique as a safety precaution is presented, with particular emphasis on the importance of maintaining negative pressure in vials. We also discuss the use of ultraviolet light to detect antineoplastic drug spills in a working environment and as a training and evaluation procedure.