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Disseminated intravascular coagulation signs appear in angina and myocardial infarction, worsening with disease severity. These coagulation changes, including reduced platelets and altered clotting factors, indicate microthrombus formation in severe cases.
Area of Science:
- Cardiology
- Hematology
- Pathophysiology
Abstract:
In patients with angina pectoris and acute myocardial infarction different signs of disseminated intravascular coagulation were found, their intensity depending on the severity of the clinical course. In myocardial infarction with a complicated course and, especially, in shock signs of disseminated intravascular microthrombus formation were revealed, its criteria including, according to the author's data, reduced platelets count, factor V activity, shortening of platelets life and period of labelled fibrinogen circulation, appearance of large quantities of the fibrin-monomer complex.