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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Spontaneous regression of colon carcinoma

A A Serpick

    National Cancer Institute Monograph
    |November 1, 1976
    PubMed

    Abstract:

    Apparent spontaneous regression of advanced colon carcinoma has been reported in 7 patients. This is a very rare event, and the circumstances accounting for this are elusive.

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    Tumor Progression

    Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
    Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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