[Inhibitory effect of parenterally administered dicarboxylic amino acids on gastric secretion]

Tests conducted on dogs established that glutaminic and aspargic acids introduced into the blood by the drip method call forth inhibition of the gastric secretion stimulated by other amino acids (alanine, glycine, proline). The dicarboxylic amino acids inhibit also the reflex phase of the gastric secretion provoked by injection of histamine. It is only against the background of a repeated introduction of histamine for many hours that they produce a sharply marked inhibitory effect. This manifests itself chiefly in dogs with denervated isolated pouches, while with intact innervation of gastric glands this effect is very poorly pronounced. Introduction of beta-adrenolytic-obsidan is attended by a drastic reduction of this effect.