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Updated: Aug 5, 2026
19:15
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Summary
Neonatal intensive care units (NICUs) frequently use antimicrobial agents. A survey found calcium gluconate often causes phlebitis, with a consensus 10% incidence, highlighting the need for standardized drug administration protocols.
Area of Science:
- Neonatal pharmacology
- Intensive care medicine
- Pediatric drug safety
Background:
- Neonatal intensive care units (NICUs) utilize a wide range of medications.
- Standardization of drug administration and monitoring for adverse events is crucial in neonates.
Purpose of the Study:
- To survey drug usage, dosages, administration methods, and phlebitis incidence in NICUs.
- To identify common causes of drug-induced phlebitis in neonates.
- To assess the sources used for drug information in NICU settings.
Main Methods:
- A national survey of neonatal intensive care units (NICUs).
- Data collection on drug usage, dosages, administration routes, and phlebitis incidence.
- Analysis of reported drug reference sources and implicated agents for phlebitis.
Main Results:
- Antimicrobial agents are the most frequently administered drugs in NICUs.
- Reported dosages generally align with manufacturer and literature recommendations.
- A consensus estimate of 10% phlebitis incidence was reported, with calcium gluconate most frequently implicated.
- Most NICUs avoid mixing drugs with hyperalimentation solutions.
Conclusions:
- Standardized review of neonatal drug dosages by Pharmacy and Therapeutic Committees is recommended.
- Establishment of uniform policies for intravenous drug administration methods and rates is essential.
- Ensuring consensus among clinicians regarding neonatal medication practices is critical for patient safety.
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