[Pathomorphological study of antiviral chemotherapeutic effectiveness of bonaphthon under experimental conditions]

A pathomorphological study of antiviral chemotherapeutic activity of benaphthon was carried out in tests involving intranasal inoculation of mice with influenza A2 (Hong Kong) 68 viruses (infection doses of 1 DL75 and 10 DL75) and of rabbits with herpetic keratitis, provoked by the herpes simplex virus (strain Ela-5699). A single prophylactic introduction of bonaphthon with subsequent 4-day treatment of experimental influenzal pneumonia of mice was found to produce a significant diminution in the frequency of the pneumonia development in experimental animals, a reduction in the number of severe and lethal forms of the malady and, by preventing the development of morphologically grave forms, to improve the prognosis. The use of bonaphthon in experimental herpetic keratitis of rabbits, irrespective of the mode of its administration (locally or by mouth) cuts down the period of the keratitis cure almost in half, contributes to a speedier epithelization of the ulcerated surface and to the disappearance of inflammatory manifestations in the very substance of the cornea.