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Plasma cell alterations in ulcerative colitis. An electron microscopic study.

J O Gebbers, H F Otto

Pathologia Europaea

|January 1, 1976

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Investigating ulcerative colitis (UC) inflammation in young patients, this study found altered plasma cells in the colon. These changes suggest an imbalance in the local immunoglobulin (Ig) system, contributing to UC pathology.

Area of Science:

Gastroenterology
Immunology
Cell Biology

Background:

Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
The colonic lamina propria mucosae in UC is infiltrated by lymphocytes, macrophages, and plasma cells.

Purpose of the Study:

To investigate the ultrastructural characteristics of plasma cells in the colonic mucosa of young patients with active UC.
To explore the functional states and potential pathological alterations of plasma cells in UC.
To assess the implications for the local immunoglobulin (Ig) system in UC.

Main Methods:

Electron microscopy was used to examine colon biopsies from 37 young patients with active UC.
Special attention was paid to the inflammatory infiltrate, particularly plasma cells.

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Analysis focused on the morphology and rough endoplasmic reticulum (RER) of plasma cells.

Main Results:

Close topographical relationships were observed between plasma cells and other inflammatory cells.
Diverse plasma cell morphologies were identified, differing in RER development and content, indicating varied functional states.
Frequent occurrence of Russell bodies, Mott cells, and necrobiotic plasma cells suggests pathological alterations.

Conclusions:

The observed plasma cell alterations in UC point towards a potentially pathological state.
These findings, combined with immunohistochemical data, support the hypothesis of an imbalanced local Ig system in UC.
Further research into the Ig system's role in UC pathogenesis is warranted.