Biochemical changes in extracorporeal circulation in patients

Area of Science:

• Cardiovascular Surgery
• Transfusion Medicine
• Clinical Chemistry

Background:

• Extracorporeal perfusion is critical during open-heart surgery.
• Blood product dilution can alter physiological parameters.
• Understanding these changes is vital for patient management.

Purpose of the Study:

• To investigate the impact of priming solutions on patient physiology.
• To assess serum electrolytes, acid-base status, and plasma osmolality.
• To evaluate plasma osmolality as a prognostic indicator.

Main Methods:

• Studied 103 patients undergoing open-heart surgery.
• Utilized 50% and 80% diluted homologous blood for pump priming.
• Monitored serum electrolytes, acid-base balance, and plasma osmolality.

Main Results:

• Priming solutions significantly affected electrolyte levels.
• Acid-base status showed notable alterations post-priming.
• Plasma osmolality changes were observed and analyzed.

Conclusions:

• Diluted homologous blood impacts key physiological markers during surgery.
• Plasma osmolality warrants further investigation for its prognostic potential.
• Optimizing priming strategies can improve patient outcomes.