[Toxicological study of an antiviral drug, bonaphthon]

The toxicity of bonaphthon was studied on laboratory animals of different species (mice, rats, guinea pigs, dogs) with its single and repeated (daily, for a space of 4 months) administration. It has been found that bonaphthon, with its single and repeated administration in doses much higher (by 16 to 32 times) than the ones recommended for human beings, is well tolerated not only by sexually mature, but also by immature animals (rats). Bonaphthon does not affect adversely the dynamic changes in the weight of the animals, nor does it have any effect on the diuresis, functional state of the gastro-intestinal tract and the cardiac activity. On its administration in toxic doses exceeding by 60 and more timesthe ones recommened for human beings the drug provokes flabbiness, bradycardia, a fall of arterial pressure and causes changes in the activity of nonspecific enzymatic systems of the liver. Among the test animals most sensitive to bonaphthon are mice.