Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Bioavailability of digoxin and beta-methyl-digoxin.

L Padeletti, F Fantini, P Cinelli

The Journal of International Medical Research

|January 1, 1976

Summary

This study found no significant differences in how the body absorbs digoxin and beta-methyl-digoxin. Both medications showed comparable bioavailability in healthy volunteers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SARS-CoV-2 in the sweat of COVID-19-positive patients: a possible route of transmission?

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

Same author

Relapse of chilblain-like lesions during the second wave of coronavirus disease 19.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021

Same author

Response to 'No evidence of SARS-CoV-2 infection by polymerase chain reaction or serology in children with pseudo-chilblain'.

The British journal of dermatology·2020

Same author

Acral cutaneous lesions in the time of COVID-19.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020

Same author

Predictors of Beta-Hexachlorocyclohexane blood levels among people living close to a chemical plant and an illegal dumping site.

Environmental health : a global access science source·2020

Same author

The Hidradenitis suppurativa patient journey in Italy: current status, unmet needs and opportunities.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016

Area of Science:

Pharmacokinetics
Drug bioavailability
Clinical pharmacology

Background:

Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
Beta-methyl-digoxin is a related compound with potential differences in absorption or metabolism.
Understanding the comparative bioavailability of different digoxin formulations is crucial for therapeutic equivalence.

Purpose of the Study:

To compare the bioavailability of a single dose of digoxin versus beta-methyl-digoxin.
To assess the rate and extent of drug absorption for both formulations.
To determine if beta-methyl-digoxin offers equivalent bioavailability to standard digoxin.

Main Methods:

A randomized crossover study design was employed.
Four healthy volunteers participated in the study.
Drug absorption was evaluated using 6-day cumulative urinary excretion and serial serum concentration measurements.

Main Results:

No statistically significant differences were observed between digoxin and beta-methyl-digoxin.
The rate and extent of drug absorption were comparable for both tested products.
Urinary excretion and serum concentrations did not reveal disparities in bioavailability.

Conclusions:

Digoxin and beta-methyl-digoxin exhibit similar bioavailability profiles.
The findings suggest therapeutic equivalence between the two formulations based on absorption parameters.
Further clinical studies may be warranted to confirm these pharmacokinetic findings.

Related Experiment Videos