[Relationship between cell division and function. Resistance of the liver to toxic effect of CCL4 after partial...

The necrogenic effect of CCL4 was used as a marker of drug metabolizing function of hepatocytes. CCL4 induced a zonal centrolobular necrosis in normal mice. After partial hepatectomy, during intensive hepatocyte proliferation, the necrosis area in the sections was seen significantly decreased. No damaged cells being observed in some instances. The resistance to hepatotoxin is explaned by inhibition of the specific cell function during proliferation.