Monoiodotyrosine: effects on tissue amines and cold survival

The effects of monoiodotyrosine (MIT) on cold survival and levels of tissue amines in rats were studied. MIT was found to impair cold suvival and to lower levels of norepinephrine (NE). These experiments confirm previous pharmacologic evidence that MIT has an anti-adrenergic effect. Cold stress lowered brain NE levels but failed to lower brain dopamine levels, a finding consistent with current views of the role of brain mechanisms in temperature regulation.