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Related Experiment Videos

A gene complex controlling segmentation in Drosophila.

E B Lewis

    Nature
    |December 7, 1978
    PubMed
    Summary
    This summary is machine-generated.

    The bithorax gene complex regulates insect development. Gene repression gradients, influenced by cis-regulatory elements and the Polycomb repressor, control thoracic and abdominal segmentation patterns in Drosophila.

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    Area of Science:

    • Developmental Biology
    • Genetics
    • Molecular Biology

    Background:

    • The bithorax gene complex in Drosophila is crucial for thoracic and abdominal development.
    • This complex comprises at least eight genes involved in developmental patterning.

    Purpose of the Study:

    • To investigate the regulatory mechanisms controlling the bithorax gene complex.
    • To understand the role of cis-regulatory elements and the Polycomb locus in gene repression and segmentation patterns.

    Main Methods:

    • Analysis of gene repression states within the bithorax complex.
    • Examination of cis-regulatory elements controlling gene expression.
    • Investigation of the Polycomb locus's function as a repressor.

    Main Results:

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    • At least four genes within the bithorax complex are regulated by cis-regulatory elements.
    • The Polycomb locus appears to encode a repressor for the bithorax complex.
    • Observed wild-type and mutant segmentation patterns correlate with predicted repressor gradients.

    Conclusions:

    • An antero-posterior gradient of repressor concentration along the embryo and a proximo-distal gradient of cis-regulatory element affinities along the chromosome explain segmentation patterns.
    • These findings elucidate the complex genetic control of body plan formation in Drosophila.