Chloride ion concentration in vaginal discharge and urine during puberty

In 27 prepubertal-pubertal girls the chloride ion concentration in vaginal discharge and urine was estimated four times during the menstrual cycle by means of a direct new micromethod using a Cl-selective electrode. In pubertal girls the chloride content showed changes both in vaginal discharge and in urine; the latter changed practically parallel with the vaginal value. A sharp rise in chloride content characteristic of normal ovulation was observed in 5 patients free from hormonal disturbances, while there were significant differences during ovulation 5 times and in the premenstrual phase 6 times in the girls with hormonal disturbances.