Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new freeze-drying technique for processing biological materials.

A Briggs

    Developments in Biological Standardization
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Assessment of alendronate and dietary treatment in the management of feline idiopathic ionised hypercalcaemia and ionised hypercalcaemia associated with chronic kidney disease: 29 cases (2016-2022).

    The Journal of small animal practice·2024
    Same author

    Predictors and moderators of the response of adults with intellectual disabilities and depression to behavioural activation and guided self-help therapies.

    Journal of intellectual disability research : JIDR·2023
    Same author

    Use of Advanced Flexible Modeling Approaches for Survival Extrapolation from Early Follow-up Data in two Nivolumab Trials in Advanced NSCLC with Extended Follow-up.

    Medical decision making : an international journal of the Society for Medical Decision Making·2022
    Same author

    Stratified medicine using invasive coronary function testing in angina: A cost-effectiveness analysis of the British Heart Foundation CorMicA trial.

    International journal of cardiology·2021
    Same author

    Type 2 diabetes remission: economic evaluation of the DiRECT/Counterweight-Plus weight management programme within a primary care randomized controlled trial.

    Diabetic medicine : a journal of the British Diabetic Association·2019
    Same author

    First Report of Tomato yellow leaf curl virus Infecting Tomato, Tomatillo, and Peppers in Guatemala.

    Plant disease·2019
    Same journal

    International challenges and public policy issues.

    Developments in biological standardization·2000
    Same journal

    Regulation of biologicals in China.

    Developments in biological standardization·2000
    Same journal

    ICH activities on biotech topics.

    Developments in biological standardization·2000
    Same journal

    Regulation of biologicals in the European Union.

    Developments in biological standardization·2000
    Same journal

    Standardisation and licensing of combination vaccines based on DTP.

    Developments in biological standardization·2000
    Same journal

    Control of foot-and-mouth disease by vaccination.

    Developments in biological standardization·2000
    See all related articles

    A novel freeze-system using Freon-12 enables ultra-rapid freezing for producing precise tablets from sensitive biological materials. This method enhances homogeneity, dissolution rates, and weight control compared to traditional techniques.

    Area of Science:

    • Pharmaceutical Technology
    • Materials Science
    • Bioprocessing

    Background:

    • Conventional tablet formulation methods like wet granulation and dry blending have limitations in producing homogeneous tablets with controlled active ingredient release.
    • Challenges exist in processing sensitive biological materials for tablet formulation due to component migration and loss of activity.

    Purpose of the Study:

    • To develop and apply a new freeze-system for processing sensitive biological materials into precise tablets.
    • To overcome limitations of existing tablet formulation techniques regarding homogeneity, dissolution, and weight control.

    Main Methods:

    • Utilized a novel freeze-system with a swirling bath of Freon-12 for ultra-rapid freezing (7-14 milliseconds) of biological materials.
    • Processed frozen beads via freeze-drying to create amorphous homogeneous spheres, retarding component migration.

    Related Experiment Videos

  • Optimized droplet size through controlled injection rate, stream diameter, and Freon-12 bath surface velocity.

    • Main Results:

    • Achieved ultra-rapid freezing, yielding amorphous homogeneous spheres with precise control over pH and redox potential.
    • Tablets exhibited exceptionally rapid dissolution (8-12 seconds), requiring specialized testing methods.
    • Demonstrated improved recovery of activity for sensitive biological materials compared to conventional freeze-drying.
    • Attained high tablet weight precision (0.6 +/- 0.06% for 50 mg tablets), significantly better than traditional methods (1-2%).

    Conclusions:

    • The Freon-12 freeze-system offers a superior method for producing precise tablets from sensitive biological materials.
    • This technology enables enhanced homogeneity, rapid dissolution, and superior weight control in tablet formulations.
    • Potential applications include advanced pharmaceutical manufacturing and the production of ultra-precise reagent tablets for automated analytical systems.