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Hormones in renal cancer
Transactions of the American Association of Genito-Urinary Surgeons
|January 1, 1976
Summary
Plasma renin and erythropoietin levels may serve as valuable biochemical tumor markers for renal adenocarcinoma. Elevated levels, particularly erythropoietin, indicate the presence of kidney cancer, with renin potentially predicting a poorer prognosis.
Area of Science:
- Oncology
- Biochemistry
- Nephrology
Background:
- Renal adenocarcinoma, a common kidney cancer, presents diagnostic challenges.
- Biochemical markers are sought to aid in early detection and prognosis.
Purpose of the Study:
- To evaluate plasma renin, erythropoietin, and chorionic gonadotropin as potential biochemical tumor markers in renal adenocarcinoma.
- To correlate marker levels with tumor characteristics and patient prognosis.
Main Methods:
- Measurement of plasma renin, erythropoietin, and chorionic gonadotropin levels in 57 patients with renal adenocarcinoma.
- Analysis of marker levels in relation to tumor grade, stage, histologic type, blood pressure, and prognosis.
Main Results:
- Elevated renin was found in 37% of patients, associated with high-grade, high-stage tumors and poor prognosis.
- Elevated erythropoietin was found in 63% of patients, more sensitive than renin but less specific.
- Chorionic gonadotropin levels were not elevated in any patient.
Conclusions:
- Renin and erythropoietin show potential as valuable biochemical tumor markers for renal adenocarcinoma.
- Erythropoietin appears more sensitive for detecting kidney cancer, while renin may offer prognostic information.