Carcinoma of the cystic duct associated with opisthorchiasis

Four patients who had obstructing carcinoma of the cystic duct and who presented themselves with enlarged and palpable gall bladders but without jaundice are reported. All patients came from endemic areas of opisthorchiasis and had evidence of Opisthorchis infection by peritoneoscopic and surgical findings. All but one had Opisthorchis eggs in the stool. The pathogenesis and management was discussed.