Effects of benzazepine (Sch-12679) on shock-induced fighting and locomotor behavior in rats

Benzazepine (Sch-12679) reduced the shock-induced fighting behavior of rats in a dose-dependent fashion. However, the drug also impaired both locomotor behavior and rotorod performance. These results suggest that the aggression suppressive effects of Sch-12679 may be mediated by drug-induced sedation.