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Updated: Sep 4, 2026

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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Effect of prolonged trifluoperazine, imipramine and haloperidol administration on serum cholesterol. An experimental
Pharmacology
|January 1, 1976
Abstract:
As a result of prolonged intragastric administration of trifluoperazine (TFZ) and imipramine in rabbits, a significant rise in serum cholesterol was observed after 4, 8 and 12 weeks. Haloperidol was ineffective. Hypercholesterolemia produced by TFZ was not associated with increased estriol excretion in urine. Histochemical examination of aorta of TFZ-treated animals showed positive 'Schultz's reaction' for cholesterol, suggesting a possible causal relationship between TFZ-induced hypercholesterolemia and atherogenesis.

