Clinical responses to T(n)BP-disrupted HDCS (WI-38) rabies vaccine

Study of 10 batches of an antirabies vaccine made from purified, concentrated subunits (Pitman-Moore strain adapted to Wistar HDCS). One single dose of vaccine is insufficient; three or more doses induce high antibody levels. Among more than 2000 vaccines secondary reactions were rare and generally mild and transient. All the individuals vaccinated post-exposure remained without rabic symptoms. The vaccine was also particularly efficacious for booster doses.