[Importance of bile for stress ulcer in the rat]

The influence of bile on ulcer formation under restraint stress condition was studied in rats. Animals with a choledochogastrostomy or a pyloroplasty showed as many ulcers as the sham-operated controls. After choledochoileostomy or bile duct ligation the ulcer frequency was reduced by half. A pharmacologic binding of the bile salts by intragastral cholestyramine had the same effect.