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[Calcium in the prevention of stress ulcer in the rat]
Abstract:
Calcium gluconate, carbonate, and lactate are potent antiulcerogenic agents when administered intragastrically at pH 6.3 by sustained infusion (45 mg/kg/8 h). In intact rats, by radioimmunologically measurable serum, gastrin and calcitonin are inversely correlated, whereas gastrin and ulcer index tend to correlate directly. The findings imply a key role for thyroid-releasable endogenous calcitonin in this disorder.