[Antibiotica release from bone cement in animal experiment]

The release of antibiotics from bone cement palacos into cortical bone after experimental ostemyelitis in sheep was demonstrated by our experiments. High carbenicillin and cephalothin concentration levels were present for 2 weeks, but after 3 weeks were no longer evident. Lincomycin and gentamicin in the first days showed high tissue levels, then decreased and increased again after the 2nd week. Gentamicin was examined over 10 months, producing high levels after this time also.