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[Antibiotica release from bone cement in animal experiment]
Langenbecks Archiv Fur Chirurgie
|January 1, 1976
Summary
Antibiotic release from bone cement in sheep with osteomyelitis was studied. High levels of carbenicillin, cephalothin, lincomycin, and gentamicin were observed for varying durations, with gentamicin showing sustained release.
Area of Science:
- Orthopedic Surgery
- Infectious Diseases
- Pharmacology
Context:
- Osteomyelitis is a challenging bone infection.
- Bone cement is used for antibiotic delivery.
- Sheep models allow for in vivo study of bone healing and infection.
Purpose:
- To quantify antibiotic release from bone cement into cortical bone.
- To evaluate the efficacy of antibiotic-loaded bone cement in an experimental osteomyelitis model.
- To determine the duration of effective antibiotic concentrations in bone tissue.
Summary:
- Antibiotic release from Palacos bone cement into cortical bone was assessed in a sheep osteomyelitis model.
- Carbenicillin and cephalothin showed high concentrations for 2 weeks, diminishing by week 3.
- Lincomycin and gentamicin exhibited initial high levels, followed by a decrease and subsequent increase after week 2. Gentamicin demonstrated sustained high levels for up to 10 months.
Impact:
- Provides crucial data on antibiotic elution profiles from bone cement.
- Informs clinical decisions regarding antibiotic selection and duration for osteomyelitis treatment.
- Highlights the potential for long-term antibiotic delivery with specific agents like gentamicin.
