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Related Experiment Videos

Diclofenac/hyaluronic acid.

D C Peters1, R H Foster

  • 1Adis International Limited, Auckland, New Zealand. demail@adis.co.nz

Drugs & Aging
|May 13, 1999
PubMed
Summary
This summary is machine-generated.

Topical diclofenac in hyaluronic acid gel effectively treats actinic keratosis, with nearly half of patients achieving clinical cure. Mild skin irritation was the most common side effect observed in clinical studies.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Biochemistry

Background:

  • Actinic keratosis (AK) is a common pre-malignant skin condition.
  • Diclofenac is a non-steroidal anti-inflammatory drug with potential anti-angiogenic properties.
  • Hyaluronic acid can enhance drug penetration and delivery.

Purpose of the Study:

  • To evaluate the efficacy and safety of a topical gel containing 3% diclofenac in 2.5% hyaluronic acid (HYAL CT1101) for actinic keratosis treatment.
  • To investigate the pharmacokinetic properties of diclofenac delivered via hyaluronic acid gel.

Main Methods:

  • A randomized, double-blind, placebo-controlled clinical trial involving 108 patients with actinic keratosis.
  • Administration of topical HYAL CT1101 or placebo for 3 months.

Related Experiment Videos

  • Assessment of clinical cure rates and incidence of skin irritation.

    • Main Results:

    • Topical HYAL CT1101 achieved a clinical cure in 47% of patients, compared to 19% for placebo after 3 months.
    • Diclofenac in hyaluronic acid demonstrated accumulation in the epidermis in vitro and in vivo.
    • Mild to moderate skin irritation was reported in up to 72% of patients using HYAL CT1101.

    Conclusions:

    • Topical diclofenac in hyaluronic acid gel is an effective treatment for actinic keratosis.
    • The formulation shows promise for localized drug delivery to the epidermis.
    • Skin irritation is a notable side effect requiring consideration in clinical practice.