Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recombination within the human MHC.

M Carrington1

  • 1IRSP, SAIC-Frederick National Cancer Institute, MD 21702, USA. carringt@mail.ncifcrf.gov

Immunological Reviews
|May 13, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterisation of the T-cell response to Ebola virus glycoprotein amongst survivors of the 2013-16 West Africa epidemic.

Nature communications·2021
Same author

Prevalence and correlates of normal body mass index central obesity among people with cardiovascular diseases in Australia.

Public health·2020
Same author

Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells.

Clinical and experimental immunology·2015
Same author

Inhibitory KIR3DL1 alleles are associated with psoriasis.

The British journal of dermatology·2015
Same author

Relation of HLA class I and II supertypes with spontaneous clearance of hepatitis C virus.

Genes and immunity·2013
Same author

F8 haplotype and inhibitor risk: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.

Haemophilia : the official journal of the World Federation of Hemophilia·2012
Same journal

Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.

Immunological reviews·2026
Same journal

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026
Same journal

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.

Immunological reviews·2026
Same journal

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

Immunological reviews·2026
Same journal

Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures.

Immunological reviews·2026
Same journal

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026
See all related articles

Recombination in the human Major Histocompatibility Complex (MHC) generates diverse Human Leukocyte Antigen (HLA) alleles and haplotypes. New methods like single-sperm typing offer insights into MHC recombination

Area of Science:

  • Immunogenetics
  • Human Genetics
  • Molecular Evolution

Background:

  • Recombination within the human Major Histocompatibility Complex (MHC) is implicated in the generation of novel Human Leukocyte Antigen (HLA) alleles.
  • It significantly contributes to the observed diversity in HLA haplotypes, though its functional impact remains unclear.
  • Previous studies using historical and family data estimated recombination fractions and identified hotspots in the MHC class II region.

Purpose of the Study:

  • To explore the role of recombination in shaping HLA haplotype diversity within the human MHC.
  • To investigate characteristics of MHC recombination, including haplotype specificity and sequence motifs.
  • To overcome limitations of human population studies by employing advanced techniques.

Main Methods:

Related Experiment Videos

  • Analysis of historical and family-based recombination data.
  • Identification of potential recombination hotspots in the MHC class II region.
  • Application of single-sperm typing to overcome population study constraints.

Main Results:

  • Recombination is a key driver of HLA allele and haplotype diversity in the human MHC.
  • Haplotype specificity and localized sequence motifs influence recombination frequency.
  • Single-sperm typing offers a promising approach to study MHC recombination dynamics.

Conclusions:

  • Recombination plays a crucial role in the evolution of HLA haplotypes.
  • Combining family-based and sperm typing analyses with linkage disequilibrium data provides novel insights into MHC evolution.
  • Further research using advanced methods is needed to fully understand the functional consequences of MHC recombination.