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Updated: Oct 13, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
Published on: March 8, 2018
Synthesis of cancer peptide antigen-lipid A analog conjugates for synthetic vaccines
K Ikeda1, K Miyajima, Y Maruyama
1School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Abstract:
Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.
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