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Sex differences in morphine-induced ventilatory depression reside within the peripheral chemoreflex loop.

E Sarton1, L Teppema, A Dahan

  • 1Department of Anesthesiology, Leiden University Medical Center, The Netherlands. E.Sarton@Anesthesiology.Medfac.LeidenUniv.nl

Anesthesiology
|May 13, 1999
PubMed
Summary

Morphine causes sex-specific ventilatory depression. Women show greater peripheral chemoreflex pathway impairment, while central pathways are equally affected in both sexes.

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Area of Science:

  • Pharmacology
  • Respiratory Physiology
  • Neuroscience

Background:

  • Investigating sex-based differences in ventilatory control.
  • Examining the effects of mu-opioid receptor agonists, specifically morphine.

Purpose of the Study:

  • To identify sex-specific sites of ventilatory depression induced by morphine.
  • To differentiate between central and peripheral chemoreflex pathway responses.

Main Methods:

  • Healthy male and female participants underwent dynamic ventilatory response testing.
  • Responses to hypercapnia and hypoxia were measured before and during morphine infusion.
  • Hypercapnic responses were analyzed for central (Gc) and peripheral (Gp) carbon dioxide sensitivities.

Main Results:

Related Experiment Videos

  • Morphine equally reduced central CO2 sensitivity (Gc) in men and women.
  • Morphine significantly reduced peripheral CO2 sensitivity (Gp) in women, but not in men.
  • Morphine more profoundly depressed the initial hyperventilatory response to hypoxia in women compared to men.

Conclusions:

  • Sex differences exist in morphine-induced ventilatory depression, primarily via the peripheral chemoreflex pathway.
  • Women exhibit greater peripheral chemoreflex depression from morphine than men.
  • Morphine's effect on sustained hypoxia response was similar across sexes.