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Extracellular protons activate K+ current in a subpopulation of frog taste receptor cells
1Institute of Cell Biophysics, Russian Academy of Science, Pushchino, Moscow. bobkov@venus.iteb.serpukhov.su
Abstract:
Based on morphological and electrophysiological criteria, two distinct subpopulations (group A and group B) taste receptor cells (TRCs) isolated from frog (Rana temporaria) taste disks were identified. TRCs from the group A were depolarized by acid stimuli which, in contrast, caused hyperpolarizing responses in group B TRCs. By using patch clamp technique we explored ion mechanisms mediating the pH dependent TRC hyperpolarization, and found that K+ conductance of TRCs from the group B increased as bath solution pH reduced. Our findings provide rationale to hypothesize that TRC from the group B express H+ gated K+ channels.
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