Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Activating separate ascending auditory pathways produces different human thalamic/cortical responses.

M D Waring1, C W Ponton, M Don

  • 1Electrophysiology Department, House Ear Institute, Los Angeles, CA 90057, USA. mwaring@hei.org

Hearing Research
|May 13, 1999
PubMed
Summary

Auditory brainstem implants (ABI) restore hearing by stimulating the cochlear nucleus. Differences in brainstem responses suggest varied pathway activation, impacting higher auditory processing in neurofibromatosis type 2 patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Food protein-induced enterocolitis syndrome due to banana: an uncommon entity.

European annals of allergy and clinical immunology·2013
Same author

Risk factors of paediatric community-acquired pneumonia.

The European respiratory journal·2011
Same author

How to treat children's pneumonia: a complex problem.

The European respiratory journal·2010
Same author

Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain.

Neurobiology of aging·2006
Same author

Nasal NO: normal values in children age 6 through to 17 years.

The European respiratory journal·2005
Same author

[Candida pneumonia in patients without definitive immunodeficiency].

Mycoses·2003

Area of Science:

  • Neuroscience
  • Audiology
  • Biomedical Engineering

Background:

  • Neurofibromatosis type 2 often necessitates bilateral acoustic tumor removal, leading to auditory nerve loss.
  • Auditory brainstem implants (ABI) offer a solution by electrically stimulating the cochlear nucleus to restore a sense of hearing.
  • Electrically evoked auditory brainstem responses (eABRs) in ABI users show diverse waveforms, indicating individual differences in auditory pathway activation.

Purpose of the Study:

  • To investigate if distinct brainstem-level auditory pathway activation in ABI subjects correlates with differences in higher-level auditory processing.
  • To explore the relationship between eABR waveform morphology and subsequent auditory evoked potentials.

Main Methods:

  • Multichannel recordings of electrically evoked middle-latency and late auditory responses were performed on two ABI subjects.

Related Experiment Videos

  • Subjects were selected based on distinct eABR waveform morphologies, representing different activation patterns.
  • Analysis focused on waveform similarity, scalp distributions, and component amplitudes.

    • Main Results:

    • Both subjects showed qualitatively similar waveforms for middle-latency and late auditory responses.
    • Quantitatively, significant differences were observed in scalp distributions and magnitudes of response components.
    • One subject exhibited bilateral activation patterns with large N1-P2 complexes, while the other showed unilateral, contralateral activation with small N1-P2 complexes.

    Conclusions:

    • Differences in ascending auditory pathway activation at the brainstem level are associated with distinct patterns of neural activity in thalamic and/or cortical auditory areas.
    • ABI stimulation can lead to varied spatial and temporal neural activity patterns in higher auditory centers.
    • This highlights the individualized nature of auditory processing following ABI implantation.