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Inflammatory response to cardiopulmonary bypass using roller or centrifugal pumps
C Baufreton1, L Intrator, P G Jansen
1Department of Thoracic and Cardiovascular Surgery, Hôpital Henri Mondor, Créteil, France.
The Annals of Thoracic Surgery
|May 13, 1999
Summary
Centrifugal (CFP) pumps during coronary artery bypass grafting showed increased complement and neutrophil activation compared to roller pumps. Post-operative inflammatory responses were similar between the two pump types.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Immunology
Background:
- The inflammatory response during cardiopulmonary bypass (CPB) can impact patient outcomes.
- Coronary artery bypass grafting (CABG) frequently utilizes CPB, with different pump technologies potentially influencing the inflammatory cascade.
Purpose of the Study:
- To prospectively evaluate and compare the inflammatory response in patients undergoing CABG using roller pumps versus centrifugal (CFP) pumps.
Main Methods:
- A randomized study of 29 CABG patients (15 roller pump, 14 CFP).
- Assessed terminal complement complex (SC5b-9) and neutrophil activation (elastase) during CPB.
- Measured cytokine production (TNF-α, IL-6, IL-8) and adhesion molecules (sELAM-1, ICAM-1) post-operatively.
Main Results:
- CFP pumps led to significantly higher SC5b-9 and elastase levels during CPB.
- Interleukin-8 levels were elevated with CFP 2 hours post-CPB initiation.
- Post-operative cytokine and adhesion molecule levels were similar between groups.
Conclusions:
- CFP pumps induce greater intraoperative complement and neutrophil activation during CABG.
- The overall post-operative inflammatory response is comparable between roller and CFP systems.