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Related Experiment Videos

Mammalian nitric oxide synthases.

D J Stuehr1

  • 1Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. stuehrd@ccf.org

Biochimica Et Biophysica Acta
|May 13, 1999
PubMed
Summary
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Nitric oxide (NO) synthase enzymes create NO from L-arginine, a key biologic molecule. This review covers NO synthase structure, function, mechanism, catalysis control, and protein interactions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Enzymology

Background:

  • Nitric oxide (NO) is a critical biologic effector molecule.
  • The nitric oxide (NO) synthase (NOS) enzyme family synthesizes NO from L-arginine.

Purpose of the Study:

  • To summarize current knowledge on NO synthase.
  • To detail NOS structure-function relationships, catalytic mechanisms, and regulatory processes.

Main Methods:

  • Literature review of NO synthase research.
  • Synthesis of information on NOS structure, function, and interactions.

Main Results:

  • Overview of NOS enzyme family characteristics.
  • Detailed summary of NOS catalytic mechanisms and regulation.

Related Experiment Videos

  • Exploration of NOS protein-protein interactions.

    • Conclusions:

    • NO synthases are crucial enzymes with complex regulatory mechanisms.
    • Understanding NOS structure and function is vital for various biological processes.
    • Further research into NOS interactions can reveal new therapeutic targets.