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Nitric oxide and iron proteins.

C E Cooper1

  • 1Department of Biological Sciences, Central Campus, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK. ccooper@essex.ac.uk

Biochimica Et Biophysica Acta
|May 13, 1999
PubMed
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Nitric oxide (NO) interactions with iron are crucial biological reactions. This review details NO

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Nitric oxide (NO) is a critical signaling molecule involved in numerous biological processes.
  • Iron is a key component in many proteins and enzymes, participating in vital cellular functions.
  • The interaction between NO and iron species is fundamental to understanding NO's biological roles.

Purpose of the Study:

  • To review the kinetics, thermodynamics, mechanisms, and biological significance of nitric oxide interactions with various iron species.
  • To elucidate the roles of NO-iron interactions in enzyme activation and inhibition.
  • To discuss the implications of NO reactions with reactive NO metabolites and iron.

Main Methods:

  • Literature review focusing on biochemical and physiological studies of nitric oxide and iron.

Related Experiment Videos

  • Analysis of reaction mechanisms, kinetics, and thermodynamics of NO-iron binding.
  • Examination of the biological consequences of these interactions in different cellular contexts.

    • Main Results:

    • Reversible binding of NO to ferrous heme activates guanylate cyclase and inhibits cytochrome oxidase.
    • NO reversibly binds to ferric iron, leading to catalase inhibition.
    • Reaction of NO with oxyhemoglobin generates nitrate and ferric heme, a major NO metabolic pathway in vasculature.
    • NO also interacts with iron-sulfur enzymes like aconitase and NADH dehydrogenase.

    Conclusions:

    • Nitric oxide's interactions with iron are central to its diverse biological functions.
    • Understanding these interactions is key to comprehending NO's roles in physiological regulation and disease.
    • Further research into NO metabolites and their iron interactions holds significant therapeutic potential.