Related Experiment Video
Updated: Oct 8, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus
E Whittaker1, E Vereker, M A Lynch
1Department of Physiology, Trinity College, Dublin 2, Ireland.
Abstract:
The effect of intracerebroventricular injection of neuropeptide Y (NPY) was assessed on LTP in dentate gyrus. We report that NPY attenuated LTP and inhibited KCl-induced glutamate release in synaptosomes prepared from dentate gyrus. Activity of the stress-activated kinase, c-Jun NH2-terminal kinase (JNK) in synaptosomes was increased by incubation with NPY or following intracerebroventricular injection. Activation of JNK might underlie the inhibitory effect of NPY on LTP.
More Related Videos
Related Concept Videos
Long-term Potentiation
Long-term Depression
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Antiepileptic Drugs: Glutamate Antagonists

