Related Experiment Video
Updated: Aug 15, 2026
08:57
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
Published on: March 26, 2015
[Peculiarities of myelin formation in the spinal roots of the rabbit]
Acta Anatomica
|January 1, 1976
Abstract:
The axon sheath formation in the ventral and dorsal spinal roots of newborn rabbits is discussed. The mesaxon grows at a greater rate than the outer plasmalemma of the Schwann cell, thereby giving rise to folds in the mesaxon. The compact myelin spiral is formed by the apposition of 2-3 lamellae.
Insights
Axon sheath formation in newborn rabbits involves Schwann cell mesaxon growth outpacing plasmalemma expansion, creating folds. This process leads to the compact myelin spiral through lamellar apposition.
Area of Science:
- Neuroscience
- Cell Biology
- Developmental Biology
Context:
- Focuses on the early stages of myelination in the central nervous system.
- Examines the cellular mechanisms underlying axon ensheathment.
Purpose:
- To elucidate the morphological dynamics during axon sheath formation.
- To describe the process by which the myelin sheath is constructed.
Summary:
- Investigates axon sheath development in rabbit spinal roots.
- Details the differential growth rates between the mesaxon and Schwann cell plasmalemma.
- Explains the formation of the compact myelin spiral from lamellar apposition.
Impact:
- Provides foundational knowledge for understanding demyelinating diseases.
- Contributes to the cellular and molecular understanding of nerve development.
- Offers insights into the biophysical processes of myelin formation.
