Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alkaline phosphatase in the thymus.

M T Rakhawy, A A Tarkhan, A M Zakaria

    Acta Anatomica
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Alkaline phosphatase activity appears in the fetal thymus around 32-36 weeks gestation, increasing with age and peaking at 10 years. Disease significantly augments this enzyme activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sensory fibres in the hypoglossal nerve.

    Journal of anatomy·2010
    Same author

    Medical informatics on the Internet: creating the sci.med. informatics newsgroup.

    Journal of the American Medical Informatics Association : JAMIA·1995
    Same author

    LabTalk/2: a middleware approach to HIS integration.

    Proceedings. Symposium on Computer Applications in Medical Care·1995
    Same author

    Trace metals in cement and in airborne cement dust.

    The Journal of the Egyptian Public Health Association·1988
    Same author

    The comparative anatomy of the blood supply of cardiac ventricles in the albino rat and guinea-pig.

    Journal of anatomy·1978
    Same author

    Alkaline phosphatase activity in the human tonsils and its relation to tonsillar diseases.

    Acta anatomica·1976

    Area of Science:

    • Biochemistry
    • Immunology
    • Histology

    Background:

    • The thymus plays a crucial role in immune system development.
    • Alkaline phosphatase (AP) is an enzyme with various physiological functions.
    • Understanding AP activity in the thymus may shed light on thymic function.

    Purpose of the Study:

    • To investigate alkaline phosphatase activity in fetal and pediatric thymuses.
    • To correlate AP activity with thymic development and disease states.
    • To explore the potential role of AP in thymic function.

    Main Methods:

    • Human thymuses from various age groups and disease states were analyzed.
    • Gomori technique was used to detect AP activity.
    • Four different phosphate esters served as substrates for enzyme activity detection.

    Related Experiment Videos

    Main Results:

    • AP activity was observed in the thymus cortex and Hassall's corpuscles, with varying patterns depending on the substrate.
    • AP activity was absent before 32-36 weeks of gestation, appearing thereafter.
    • Enzyme activity increased during fetal development, peaked around 10 years of age, and then declined.
    • Significant augmentation of AP activity was noted in thymuses affected by diseases impacting the lymphoid complex.

    Conclusions:

    • Alkaline phosphatase activity is developmentally regulated in the human thymus.
    • Disease states, particularly those affecting lymphoid tissue, profoundly influence thymic AP activity.
    • The findings suggest a potential link between thymic AP and immune function, possibly related to lymphocyte-stimulating factors.