Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cutaneous neural neoplasms--an update].

T Mentzel1

  • 1Institut für Pathologie der Friedrich-Schiller-Universität Jena.

Der Pathologe
|May 13, 1999
PubMed
Summary
This summary is machine-generated.

Recent advances in immunohistochemistry and electron microscopy have identified distinct benign cutaneous neural tumors beyond neurofibromas and schwannomas. Understanding these unique neoplasms, including neurothekeoma and perineurioma, is crucial for accurate diagnosis and avoiding misclassification.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metachronous primary secretory carcinomas of the eyelid and the parotid gland.

Journal of cutaneous pathology·2023
Same author

[Infiltration of the skull by dedifferentiated cutaneous leiomyosarcoma].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2021
Same author

[Subcutaneous nodule on the lower leg of an 87-year-old man].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2021
Same author

[Digital papillary adenocarcinoma : Four case reports with brief literature review].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2018
Same author

An enlarging pedunculated nodule on the shoulder of a 21-year-old man.

Clinical and experimental dermatology·2018
Same author

Congenital dermatofibrosarcoma protuberans clinically mimicking a melanocytic naevus treated with serial excisions.

Journal of the European Academy of Dermatology and Venereology : JEADV·2017
Same journal

[Connective (tissue) pathology: What brings us together!]

Der Pathologe·2022
Same journal

[Giant cell-containing tumors of bone and differential diagnoses].

Der Pathologe·2022
Same journal

[Automation and application of robotics in the pathology laboratory].

Der Pathologe·2022
Same journal

[Practical diagnostic aspects of uterine leiomyosarcoma in the context of the 2020 WHO classification].

Der Pathologe·2022
Same journal

[Artificial intelligence: a solution for the lack of pathologists?]

Der Pathologe·2022
Same journal

[Predictive immunocytochemistry in non-small cell lung carcinoma].

Der Pathologe·2022
See all related articles

Area of Science:

  • Dermatopathology
  • Surgical Pathology
  • Oncology

Context:

  • Benign cutaneous neural tumors were previously broadly categorized as peripheral nerve sheath tumors (PNST).
  • Recent advancements in immunohistochemistry and electron microscopy have enabled the identification of new neural tumor entities.
  • Distinguishing these neoplasms is vital to prevent diagnostic errors and misdiagnosis of aggressive tumors.

Purpose:

  • To delineate distinct benign cutaneous neural neoplasms.
  • To highlight the diagnostic features of neurothekeoma and perineurioma.
  • To provide an overview of recently described neural tumor entities.

Summary:

  • Neurothekeoma presents in classical (myxoid) and cellular forms with distinct histological and immunohistochemical profiles (S-100 positive vs. S-100 negative/NKIC3 positive).

Related Experiment Videos

  • Solitary circumscribed neuroma (palisaded encapsulated neuroma) is a well-circumscribed dermal neoplasm positive for S-100 protein and neurofilaments.
  • Perineurioma, a rare subcutaneous neoplasm, exhibits spindle cells positive for vimentin and EMA, but negative for S-100 protein.

    • Impact:

    • Improved diagnostic accuracy for benign cutaneous neural tumors.
    • Reduced misdiagnosis of potentially aggressive neoplasms.
    • Enhanced understanding of the spectrum of neurothekeoma and related entities.