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Examination of Thymic Positive and Negative Selection by Flow Cytometry
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Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

T-cell development: a role for self-peptides in positive selection

C A Janeway1

  • 1Section of Immunobiology, Yale University School of Medicine, The Howard Hughes Medical Institute, New Haven, Connecticut, 06520-8011, USA.

Current Biology : CB
|May 14, 1999
PubMed

An important issue for immunologists is the difference between the two main processes that determine the mature repertoire of T-cell receptors, termed positive and negative selection. Recent papers have addressed the role of self-peptides in the process of positive selection.

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