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Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes
Published on: December 20, 2014
Centromere proteins and chromosome inheritance: a complex affair
K W Dobie1, K L Hari, K A Maggert
1Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA. kdobie@aim.salk.edu
Abstract:
Centromeres and the associated kinetochores are involved in essential aspects of chromosome transmission. Recent advances have included the identification and understanding of proteins that have a pivotal role in centromere structure, kinetochore formation, and the coordination of chromosome inheritance with the cell cycle in several organisms. A picture is beginning to emerge of the centromere-kinetechore as a complex and dynamic structure with conservation of function at the protein level across diverse species.
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