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B cell memory and the long-lived plasma cell
M G McHeyzer-Williams1, R Ahmed
1Duke University Medical Center, Department of Immunology, Durham, NC 27710, USA. mchey002@acpub.duke.edu
Current Opinion in Immunology
|May 14, 1999
Abstract:
The germinal center reaction is pivotal to the induction of B cell memory. The signals that regulate this complex microenvironment, with their cellular and molecular consequences, underpin long-term protective immunity. Recent studies have identified many key regulators of the germinal center cycle and have revealed an array of cellular outcomes that further define the memory B cell compartment.