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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Published on: April 16, 2015

Helper T cell differentiation

S L Swain1

  • 1Trudeau Institute, PO Box 59, Algonquin Avenue, Saranac Lake, NY 12983, USA. sswain@northnet.org

Current Opinion in Immunology
|May 14, 1999
PubMed

The differentiation of Th cells is regulated at different points by antigen and by other factors in a complex fashion that allows impressive flexibility in the T cell response generated and enables close control at multiple points to prevent an unwanted response. Studies over the past two years have uncovered several principles of this regulation, including a new appreciation of the critical role of survival factors in determining the success of the immune response. New insights into the details of CD4(+) T cell regulation will provide important clues as to how immune responses are regulated, in particular the generation of effector responses and development of long-lived immunity.

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